I've had two P22's. Just sold my wife's which was identical to mine except her's had a fake suppressor. Mine has a Walther Top Point II red dot scope, and a Tac62 suppressor. Very very quiet gun, but lacks in accuracy at any real distance.
Will probably buy a MKIII 22/45 here soon and call up Tactical Solutions and order their threaded 4.5" Pac-lite upper for it and throw on the Tactical Innovations suppressor we have. Mmm... would be an awesome set up. Very accurate, and scary quiet. Or go with the GemTech Oasis integral suppressor.
Can't go wrong with a Ruger .22 for accurate, and reliable, fun plinking. Grew up shooting my dad's, and it was always a blast.
ETA- Woohoo! Finally ordered a MKIII!