The impact point of a bullet varies by bullet weight and user, the best thing to do is to find out where the ammo you use impacts when you are shooting. Most people prefer point of aim impact, six o'clock hold is used for target shooting, it's great for punching holes in paper where the bullseye is always at a constant range and consistent black bulls eye size.
The answer depends on how the M&P is set up. My USP is zeroed in at 25 meters. A 6:00 hold will make it hit bullseye at 25 meters. The same hold at 21 feet will make it hit low. I haven't shot my new M&P enough to know if it is similar to my USP, but I would suspect that it is.
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